Can the seed be reversed in functional connectivity analysis?

Dear CONN community,

In functional connectivity (FC) analysis, can we use the results of a FC as a seed and do further FC analysis?
i.e. Use region A as seed and get region B as the result of a FC then use region B as seed to see where else do we get FC to in addition to region A.

Is such a reversed seed analysis accepted as valid? Or is it considered double dipping?

Thanks,
Pradeep
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Auditory Cognition Group,
Medical School, Newcastle University,
Newcastle Upon Tyne, NE2 4HH, U.K.

Website: http://www.auditorycognition.org/pradeep
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