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2nd level analysis - ROIs lack symmetry

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Dear Alfonso,

I was hoping you might be able to help me with a query regarding second-level analysis in CONN.

I have conducted a gPPI analysis (bivariate regression). I have a patient group, and a control group, and a block design task. I am aiming to look at differences in connectivity between the patient and control group during the task.

My question is this:

When I select ROI-A i obtain a beta and a p value for the connectivity with ROI-B. However, when I select ROI-B the values are different. I have checked the forum and one explanation I read explains why FDR corrected p values might be different. However I am seeing differences in the uncorrected values.

Any explanation would be most helpful!

Many Thanks,

Rob

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