Dear Conn users,
I am using the following setup: 10CTR, 1 patient. I am interested in seed-to-voxel analysis and I model [1 -1 ] for the patient and the CTRs respectively.
My issue raises at the positive/negative contrasts. When I ask for positive, essentially I am looking for connectivity that is higher in the patient than in controls with this seed and I confirm my prediction. However, when I ask for the negative (I guess this means looking for for connectivity that is higher in the controls than the patient), my prediction fails. In other words, I know already that my CTRs have higher connectivity in these regions (also see them with one-sample t-tests). but this does not survive multiple comparisons (high p<0.01, cluster-mass FDR p<0.05). I need this sanity check in order to go on with further analyses.
Do you think that this is a matter of power? How do you suggest that I proceed best?
Thanks in advance,
Athena
I am using the following setup: 10CTR, 1 patient. I am interested in seed-to-voxel analysis and I model [1 -1 ] for the patient and the CTRs respectively.
My issue raises at the positive/negative contrasts. When I ask for positive, essentially I am looking for connectivity that is higher in the patient than in controls with this seed and I confirm my prediction. However, when I ask for the negative (I guess this means looking for for connectivity that is higher in the controls than the patient), my prediction fails. In other words, I know already that my CTRs have higher connectivity in these regions (also see them with one-sample t-tests). but this does not survive multiple comparisons (high p<0.01, cluster-mass FDR p<0.05). I need this sanity check in order to go on with further analyses.
Do you think that this is a matter of power? How do you suggest that I proceed best?
Thanks in advance,
Athena