Hi Alfonso and the rest of the community.
I am trying to perform a connectivity analysis in stroke patients (Stroke patients vs Controls). I have binary masks that delimit the lesion (1 inside the lesion, 0 outside) in the native space of the stroke subjects (one mask per subject). As a potential strategy to regress lesion effects I have planned to include lesion masks in the TPM of the CSF of stroke subjects (as proposed in this paper https://doi.org/10.3389/fnhum.2017.00091). Browsing the CONN forum I found a post in which you advise to modify the spm TPM in order to contemplate the lesion as a new tissue type (https://www.nitrc.org/forum/message.php?msg_id=32176). What strategy should I follow? Would it be correct/possible to modify the CSF maps generated by CONN during segmentation (concatenate them with the lesion maps of each subject) to regress lesion-linked effects during the denoising step? Or, should I just create a mask that contains all the lesions in the stroke group and include it as a new tissue class in the SPM TPM.nii file?
Apologies in advance if this is an absurd and/or poorly formulated question.
Benxa.
I am trying to perform a connectivity analysis in stroke patients (Stroke patients vs Controls). I have binary masks that delimit the lesion (1 inside the lesion, 0 outside) in the native space of the stroke subjects (one mask per subject). As a potential strategy to regress lesion effects I have planned to include lesion masks in the TPM of the CSF of stroke subjects (as proposed in this paper https://doi.org/10.3389/fnhum.2017.00091). Browsing the CONN forum I found a post in which you advise to modify the spm TPM in order to contemplate the lesion as a new tissue type (https://www.nitrc.org/forum/message.php?msg_id=32176). What strategy should I follow? Would it be correct/possible to modify the CSF maps generated by CONN during segmentation (concatenate them with the lesion maps of each subject) to regress lesion-linked effects during the denoising step? Or, should I just create a mask that contains all the lesions in the stroke group and include it as a new tissue class in the SPM TPM.nii file?
Apologies in advance if this is an absurd and/or poorly formulated question.
Benxa.