[color=#000000]Dear Christopher,[/color]
[color=#000000]For this design you would typically create two conditions in the [i]Setup.Conditions [/i]tab (e.g. 'control' and 'experimental') and assign the stimulation blocks onsets/durations during the first-run only to the 'control' condition (e.g. select all subjects in the 'subjects' list and 'control' in the conditions list, then select 'session1' in the sessions list and enter there the corresponding onsets/durations; last select 'session2' in the sessions list and leave empty -or enter empty brackets [ ]- in the onset/duration fields) , and the stimulation blocks onsets/durations during the second-run only to the 'experimental' condition (e.g. same as above but now select session1 and leave empty the onset/durations and then select session2 and enter the appropriate onset/duration values there). [/color]
[color=#000000]Then when you get to the [i]second-level results[/i] tab you will have the 'control' and 'experimental' conditions listed there in the 'conditions' list, and you can specify any desired within- and between-subject contrasts there (e.g. select both conditions and a [-1 1] contrast to evaluate the difference in connectivity between the two conditions; doing this while selecting 'AllSubjects' in the subject-effects list performs a paired t-test between your two conditions; doing the same while selecting 'Group1' and 'Group2' in the subject-effects list and entering there also a [-1 1] contrast will look at the 2x2 ANOVA interaction between groups -a between-subjects factor- and conditions -a within-subjects factor-). [/color]
note: I am assuming that the VAS-rating blocks are to be treated as nuisance effects so you could simply include those as an additional first-level covariates, if you prefer to look at the connectivity values within those blocks as well you could instead simply define two additional conditions (e.g. 'control_VAS' and 'experimental_VAS' with the corresponding onset/duration values for the first and second sessions, respectively)
[color=#000000]Hope this helps[/color]
[color=#000000]Alfonso[/color]
[i]Originally posted by Christopher Milde:[/i][quote]Dear CONN experts,
I started using CONN to perform task-related fc analysis with a blocked-design. I can perform nice between group comparisons. However I get stucked when trying to formulate a between session comparison within subjects.
At which stage an how can I contrast both sessions (run 1 versus run 2 corresponding to experimental versus control condition within subject)?
I have the following design: 2 groups (patients, yoked controls) x 2 conditions (2 runs: first experimental condition, second control condition) both runs have a regressor of interest (stimulation) and an additional nuisance regressor (blocks were VAS-ratings were performed).
I used two session per subject were I upload the run with the experimental run (session 1) and the control run (session 2). For both runs per subject I formulated a stimulation and rating regressor as condition names
Many thanks for your support,
Chris[/quote]
[color=#000000]For this design you would typically create two conditions in the [i]Setup.Conditions [/i]tab (e.g. 'control' and 'experimental') and assign the stimulation blocks onsets/durations during the first-run only to the 'control' condition (e.g. select all subjects in the 'subjects' list and 'control' in the conditions list, then select 'session1' in the sessions list and enter there the corresponding onsets/durations; last select 'session2' in the sessions list and leave empty -or enter empty brackets [ ]- in the onset/duration fields) , and the stimulation blocks onsets/durations during the second-run only to the 'experimental' condition (e.g. same as above but now select session1 and leave empty the onset/durations and then select session2 and enter the appropriate onset/duration values there). [/color]
[color=#000000]Then when you get to the [i]second-level results[/i] tab you will have the 'control' and 'experimental' conditions listed there in the 'conditions' list, and you can specify any desired within- and between-subject contrasts there (e.g. select both conditions and a [-1 1] contrast to evaluate the difference in connectivity between the two conditions; doing this while selecting 'AllSubjects' in the subject-effects list performs a paired t-test between your two conditions; doing the same while selecting 'Group1' and 'Group2' in the subject-effects list and entering there also a [-1 1] contrast will look at the 2x2 ANOVA interaction between groups -a between-subjects factor- and conditions -a within-subjects factor-). [/color]
note: I am assuming that the VAS-rating blocks are to be treated as nuisance effects so you could simply include those as an additional first-level covariates, if you prefer to look at the connectivity values within those blocks as well you could instead simply define two additional conditions (e.g. 'control_VAS' and 'experimental_VAS' with the corresponding onset/duration values for the first and second sessions, respectively)
[color=#000000]Hope this helps[/color]
[color=#000000]Alfonso[/color]
[i]Originally posted by Christopher Milde:[/i][quote]Dear CONN experts,
I started using CONN to perform task-related fc analysis with a blocked-design. I can perform nice between group comparisons. However I get stucked when trying to formulate a between session comparison within subjects.
At which stage an how can I contrast both sessions (run 1 versus run 2 corresponding to experimental versus control condition within subject)?
I have the following design: 2 groups (patients, yoked controls) x 2 conditions (2 runs: first experimental condition, second control condition) both runs have a regressor of interest (stimulation) and an additional nuisance regressor (blocks were VAS-ratings were performed).
I used two session per subject were I upload the run with the experimental run (session 1) and the control run (session 2). For both runs per subject I formulated a stimulation and rating regressor as condition names
Many thanks for your support,
Chris[/quote]